| Identification | Back Directory | [Name]
Gandotinib | [CAS]
942577-31-3 | [Synonyms]
Gandotinib
cyclic-R-R-R-R-R-R-R
Cyclo(L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl) | [Molecular Formula]
C42H84N28O7 | [MDL Number]
MFCD34567045 | [MOL File]
942577-31-3.mol | [Molecular Weight]
1093.32 |
| Hazard Information | Back Directory | [Uses]
NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections[1][2]. | [in vivo]
NP213 (25 mg/kg) is well tolerated in mice. In Murine models of acute disseminated candidiasis, NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h[3]. | [References]
[1] Mercer DK,et al. Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02117-18 DOI:10.1128/AAC.02117-18
[2] Neelabh, et al. Sequential and Structural Aspects of Antifungal Peptides from Animals, Bacteria and Fungi Based on Bioinformatics Tools.Probiotics Antimicrob Proteins.?2016 Jun;8(2):85-101. DOI:10.1007/s12602-016-9212-3
[3] Novamycin?/NP339 Technology Summary |
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cjbscvictory
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YantaiBio
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Fuan Bio
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15002819872 |
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fuanbio.com / www.fuanbio.com |
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