| Identification | Back Directory | [Name]
CCT129202 | [CAS]
942947-93-5 | [Synonyms]
CS-407
CCT129202
CCT129202 USP/EP/BP
CCT129202
(CCT-129202
2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(th
2-[4-[6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(thiazol-2-yl)acetamide | [Molecular Formula]
C23H25ClN8OS | [MDL Number]
MFCD26405689 | [MOL File]
942947-93-5.mol | [Molecular Weight]
497.02 |
| Chemical Properties | Back Directory | [density ]
1.427 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 1 mg/mL (2.01 mM; Need ultrasonic) | [form ]
Powder | [pka]
9.26±0.50(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
QYKHWEFPFAGNEV-UHFFFAOYSA-N | [SMILES]
N1(CC(NC2=NC=CS2)=O)CCN(C2C(Cl)=CN=C3NC(C4=CC=C(N(C)C)C=C4)=NC3=2)CC1 |
| Hazard Information | Back Directory | [Uses]
CCT129202 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively. | [Biological Activity]
CCT129202 is an ATP-competitive pan-Aurora inhibitor with IC50s of 0.042 μM, 0.198 μM and 0.227 μM for Aurora A, Aurora B and Aurora C, respectively, and has a weaker effect on FGFR3, GSK3β, PDGFRβ, etc. | [in vivo]
CCT129202 at a dose of 100 mg/kg subcutaneously injected HCT116 colon xenografts in athymic mice, after 30 minutes, caused a ~50% decrease in histone H3 phosphorylation, and after 9 days of treatment, significantly inhibited tumor growth, compared with the control group , inhibited by 57.7%. | [target]
Aurora A | [IC 50]
Aurora A: 42 nM (IC50); Aurora B: 198 nM (IC50); Aurora C: 227 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Chan F, et al. Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57. DOI:10.1158/1535-7163.MCT-07-2156 |
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| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Telephone: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
DebyeTec.com Inc.
|
| Telephone: |
18086626237 18086626237 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList16955/0.htm |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|