| Identification | Back Directory | [Name]
N-(2'-(R)-hydroxyarachidoyl)-D-erythro-sphingosine | [CAS]
943147-54-4 | [Synonyms]
20:0(2R-OH) Ceramide
N-(2'-(R)-hydroxyarachidoyl)-D-erythro-sphingosine
N-(2'-(R)-hydroxyarachidoyl)-D-erythro-sphingosine
N-(2'-(R)-HYDROXYARACHIDOYL)-D-ERYTHRO-SPHINGOSINE;20:0(2R-OH) CERAMIDE
Eicosanamide, 2-hydroxy-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-, (2R)- | [Molecular Formula]
C38H75NO4 | [MOL File]
943147-54-4.mol | [Molecular Weight]
610.01 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
powder | [InChIKey]
CFYLSUZUMMPFNC-PLHXSOCRSA-N | [SMILES]
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCCCCCC)=O)CO |
| Hazard Information | Back Directory | [Uses]
Ceramides containing 2-hydroxy fatty acids (hFA) group are mainly found in the epidermis. 20:0(2R-OH) Ceramide is a 2R hydroxylated arachidic acid-containing ceramide. | [Biological Activity]
Hydroxy fatty acid (hFA)-sphingolipids play a vital role in cell signaling. hFA-ceramides contribute to the permeability barrier function of the surface epithelium of the skin. Fatty acid 2-hydroxylase (FA2H) catalyzes the synthesis of hFA-ceramides. Impaired function of FA2H causes nervous system disorders leukodystrophy and spastic paraparesis in humans. hFA-ceramides are essential for PM02734an antitumor drug to exhibit its activity. |
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