| Identification | Back Directory | [Name]
Cdk4 Inhibitor V - CAS 943746-57-4 - Calbiochem | [CAS]
943746-57-4 | [Synonyms]
Cdk4 Inhibitor V - CAS 943746-57-4 - Calbiochem
1,3(2H,4H)-Isoquinolinedione, 4-[[[(4-hydroxy-5-propoxy-2-pyridinyl)methyl]amino]methylene]-6-iodo- | [Molecular Formula]
C19H18IN3O4 | [MOL File]
943746-57-4.mol | [Molecular Weight]
479.27 |
| Chemical Properties | Back Directory | [Boiling point ]
768.1±60.0 °C(Predicted) | [density ]
1.694±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 50mg/mL | [form ]
powder | [pka]
4.69±0.48(Predicted) | [color ]
caramel | [SMILES]
O=C(/C1=C\NCC2=CC(O)=C(OCCC)C=N2)NC(C3=C1C=C(I)C=C3)=O |
| Hazard Information | Back Directory | [Uses]
A cell-permeable and metabolically stable (t1/2 >30 min at 37 °C in the presence of rat liver microsomes, NADPH, and UDPGA) pyridinylmethylamino-isoquinoline dione that acts as a potent, ATP-binding site-targeting inhibitor against Cdk4/D1 kinase activity (IC50 = 30 nM in cell-free Rb c-terminal fragment phosphorylation assays) and an effective antiproliferative agent against HCT116 colorectal and MCF-7 breast cancer cultures (IC50 = 0.73 and 0.88 µM, respectively), while affecting Cdk2/E and Cdk1/B kinase activities only at much higher concentrations (IC50 = 1.6 and 25.3 µM, respectively). |
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| Company Name: |
Merck KGaA
|
| Telephone: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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