| Identification | Back Directory | [Name]
SMER18 | [CAS]
944153-47-3 | [Synonyms]
SMER18
CS-2054
Reaxys ID: 18302282
2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)- | [Molecular Formula]
C16H14ClNO2 | [MDL Number]
MFCD01571750 | [MOL File]
944153-47-3.mol | [Molecular Weight]
287.74 |
| Chemical Properties | Back Directory | [Boiling point ]
458.7±45.0 °C(Predicted) | [density ]
1.298±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.83±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.
Target: mTOR
SMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential. | [References]
[1] Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338. DOI:10.1038/nchembio883 |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|