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945170-74-1

945170-74-1 Structure

945170-74-1 Structure
IdentificationBack Directory
[Name]

DS-22-inf-021
[CAS]

945170-74-1
[Synonyms]

DS-22-inf-021
Hazard InformationBack Directory
[Uses]

DS-22-inf-021 is a neuraminidase (NA) inhibitor. DS-22-inf-021 has antiviral activity against influenza viruses[1].
[in vivo]

DS-22-inf-021 (20-100 mg/kg, i.p., twice daily for 5 days and monitored for 14 days. ) increased survival rate in mice infected with IAV and IBV[1].

Animal Model:8-week-old female BALB/c mice, intranasally inoculated with 50 μL of five 50 % mouse lethal doses of IAV and IBV[1].
Dosage:20, 50 and 100 mg/kg
Administration:After 2 h post-infection, i.p. injection
Result:Reached 85 % protection at 100 mg/kg dose. For the B/Samara/32/2018 strain, it was observed that 100 % of mice treated with DS-22-inf-021 at 100 mg/kg.
[References]

[1] Izmailyan R, et al. Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results. Antiviral Res. 2024 Feb;222:105818. DOI:10.1016/j.antiviral.2024.105818
945170-74-1 suppliers list
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: 021-QQ:65489617 15618227136
Website: www.atkchemical.com/
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Tel: 15865264761
Website: www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm
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