| Identification | Back Directory | [Name]
Halleridone | [CAS]
94535-01-0 | [Synonyms]
Halleridone
3,3a,7,7a-Tetrahydro-3a-hydroxybenzofuran-6(2H)-one
3a-Hydroxy-2,3,3a,7a-tetrahydro-6(7H)-benzofuranone
cis-3,3a,7,7a-tetrahydro-3a-hydroxy-6(2H)-benzofuranone
6(2H)-Benzofuranone, 3,3a,7,7a-tetrahydro-3a-hydroxy-, (3aR,7aR)-rel- | [Molecular Formula]
C8H10O3 | [MOL File]
94535-01-0.mol | [Molecular Weight]
154.16 |
| Hazard Information | Back Directory | [Uses]
rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS (HY-D1056), thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production[1]. | [References]
[1] Jin Hee Kim, et al. Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF-kappaB and p38 MAP kinase activity in LPS-stimulated RAW 264.7 cells. Biochem Pharmacol. 2006 Apr 14;71(8):1198-205. DOI:10.1016/j.bcp.2005.12.031 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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