| Identification | Back Directory | [Name]
BNC105P | [CAS]
945771-96-0 | [Synonyms]
BNC105P
BNC105P(BNC-105P)
JQYGYJSOLNMXOF-UHFFFAOYSA-N
[6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran-7-yl] phosphate
[6-Methoxy-2-methyl-7-(phosphonooxy)-3-benzofuranyl](3,4,5-trimethoxyphenyl)methanone sodium salt
Methanone, [6-methoxy-2-methyl-7-(phosphonooxy)-3-benzofuranyl](3,4,5-trimethoxyphenyl)-, disodium salt | [Molecular Formula]
C20H22NaO10P | [MOL File]
945771-96-0.mol | [Molecular Weight]
476.35 |
| Hazard Information | Back Directory | [Uses]
BNC105P is a phosphate prodrug of BNC105 (HY-16114), that exhibits activity as a vascular disrupting agent (VDA) and an antitumor agent through conversion to active BNC105[1]. | [References]
[1] Rischin D, et al., Clinical, pharmacodynamic, and pharmacokinetic evaluation of BNC105P: a phase I trial of a novel vascular disrupting agent and inhibitor of cancer cell proliferation. Clin Cancer Res. 2011 Aug 1;17(15):5152-60. DOI:10.1158/1078-0432.CCR-11-0937 |
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