| Identification | Back Directory | [Name]
Glucocorticoid Resistance Inhibitor | [CAS]
947018-15-7 | [Synonyms]
J9
Glucocorticoid Resistance Inhibitor | [Molecular Formula]
C12H12N4 | [MDL Number]
MFCD11051713 | [MOL File]
947018-15-7.mol | [Molecular Weight]
212.25 |
| Chemical Properties | Back Directory | [Boiling point ]
449.7±55.0 °C(Predicted) | [density ]
1.289±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 10 mg/ml | [form ]
A crystalline solid | [pka]
2.99±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
J9 is a Glucocorticoid resistance inhibitor. J9 Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL). | [Uses]
J9 is a small molecule that reverses Dexamethasone (HY-14648) resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC50 of 28 μM in combination with Dexamethasone[1]. | [References]
[1] Cantley AM, et al. Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL). ACS Med Chem Lett. 2014 Apr 25;5(7):754-9. DOI:10.1021/ml500044g |
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| Company Name: |
Key Organics Ltd.
|
| Tel: |
+44 (0) 1840-212137 |
| Website: |
www.keyorganics.net |
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