| Identification | Back Directory | [Name]
2-(4-AMino-1H-pyrazol-1-yl)ethanol | [CAS]
948571-47-9 | [Synonyms]
4-Aminopyrazole-1-ethanol
2-(4-Amino-1H-pyrazol-1-yl)
1H-Pyrazole-1-ethanol, 4-amino- | [Molecular Formula]
C5H9N3O | [MDL Number]
MFCD11147853 | [MOL File]
948571-47-9.mol | [Molecular Weight]
127.14 |
| Chemical Properties | Back Directory | [Boiling point ]
337.9±22.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
14.42±0.10(Predicted) | [Appearance]
Brown to dark brown Solid |
| Hazard Information | Back Directory | [Synthesis]
Synthesis of compound 22.2. To a 50 mL round bottom flask was added 1-(2-hydroxyethyl)-4-nitro-1H-pyrazole (100 mg, 0.64 mmol, 1.00 eq.), methanol (5 mL) and palladium carbon (20 mg). The reaction mixture was stirred at room temperature under hydrogen atmosphere for 1 hour. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to afford 70 mg (87% yield) of 2-(4-amino-1H-pyrazol-1-yl)ethanol (Compound 22.2) as an off-white oil. | [References]
[1] Patent: WO2016/42341, 2016, A1. Location in patent: Page/Page column 184
[2] Patent: WO2015/164374, 2015, A1. Location in patent: Paragraph 00338; 00339
[3] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0342; 0344
[4] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 00081
[5] Patent: WO2007/99326, 2007, A1. Location in patent: Page/Page column 113 |
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Cool Pharm, Ltd
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Wuxi AppTec
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