| Identification | Back Directory | [Name]
5-[[6-(3,5-Dimethoxyphenyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid | [CAS]
949164-80-1 | [Synonyms]
NP603
FGF Receptor Tyrosine Kinase Inhibitor IV, NP603
5-[[6-(3,5-Dimethoxyphenyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
1H-Pyrrole-3-propanoic acid, 5-[[6-(3,5-dimethoxyphenyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-
(Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid | [Molecular Formula]
C26H26N2O5 | [MDL Number]
MFCD18632551 | [MOL File]
949164-80-1.mol | [Molecular Weight]
446.49 |
| Chemical Properties | Back Directory | [Melting point ]
252-254 °C | [Boiling point ]
698.7±55.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥30mg/mL | [form ]
powder | [pka]
4?+-.0.10(Predicted) | [color ]
orange-red |
| Hazard Information | Back Directory | [Uses]
NP603 is a potent inhibitor of FGF receptor 1, exhibiting remarkable activity against endothelial proliferation in HUVEC cells stimulated by rhFGF-2, with a minimum effective dose of 0.4 microM. | [References]
[1] Novel inhibitor for fibroblast growth factor receptor tyrosine kinase |
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