| Identification | Back Directory | [Name]
4-Piperidinecarboxamide, N-(4-bromo-3-methylphenyl)-1-[1-[(3-fluorophenyl)methyl]-1H-benzimidazol-2-yl]- | [CAS]
950403-60-8 | [Synonyms]
iPAF1C
4-Piperidinecarboxamide, N-(4-bromo-3-methylphenyl)-1-[1-[(3-fluorophenyl)methyl]-1H-benzimidazol-2-yl]- | [Molecular Formula]
C27H26BrFN4O | [MOL File]
950403-60-8.mol | [Molecular Weight]
521.42 |
| Hazard Information | Back Directory | [Uses]
iPAF1C is a potent inhibitor of polymerase-associated factor 1 complex (PAF1C). iPAF1C has anti-HIV activity[1]. | [References]
[1] Shimaa H A Soliman, et al. Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C. Sci Adv. 2023 Mar 10;9(10):eadf2468. DOI:10.1126/sciadv.adf2468 |
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