| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C,protect from light | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water: 125 mg/mL (199.17 mM) | [Sequence]
Tyr-{d-Ala}-Gly-{Me-Phe}-Gly-ol |
| Hazard Information | Back Directory | [Uses]
DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR[1]. | [Definition]
ChEBI: (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin is a peptide. | [in vivo]
DAMGO (i.v., 0.5-2 mg/kg) TFA can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective and long-lasting analgesic effect[4].
| [IC 50]
μ Opioid Receptor/MOR | [References]
[1] FEBS Lett. 1995 Jan 2;357(1):93-7. Onogi T, et al. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops. DOI:10.1016/0014-5793(94)01341-w
[2] Patel JP, et al. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol. 2006 Dec;12(6):492-500. DOI:10.1080/13550280601064798
[3] Gold MS, et al. DAMGO inhibits prostaglandin E2-induced potentiation of a TTX-resistant Na+ current in rat sensory neurons in vitro. Neurosci Lett. 1996 Jul 12;212(2):83-6. DOI:10.1016/0304-3940(96)12791-9
[4] Desmeules JA, et al. Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain. Pain. 1993 Jun;53(3):277-285. DOI:10.1016/0304-3959(93)90224-D |
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