| Identification | Back Directory | [Name]
4-Piperidinone, 3,5-bis[(4-hydroxy-3-methoxyphenyl)methylene]-, (3E,5E)- | [CAS]
950665-12-0 | [Synonyms]
FLDP-5
4-Piperidinone, 3,5-bis[(4-hydroxy-3-methoxyphenyl)methylene]-, (3E,5E)- | [Molecular Formula]
C21H21NO5 | [MOL File]
950665-12-0.mol | [Molecular Weight]
367.4 |
| Hazard Information | Back Directory | [Uses]
FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells[1]. | [References]
[1] Razali NSC, et al. Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells. Sci Rep. 2022 Jul 30;12(1):13131. DOI:10.1038/s41598-022-16274-4 |
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