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950688-14-9

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950688-14-9 Structure

950688-14-9 Structure
IdentificationBack Directory
[Name]

Timapiprant sodium
[CAS]

950688-14-9
[Synonyms]

OC000459 SODIUM
Timapiprant sodium
Timapiprant sodium (OC000459)
Timapiprant Sodium (OC000459 Sodium)
[Molecular Formula]

C21H18FN2NaO2
[MDL Number]

MFCD32182636
[MOL File]

950688-14-9.mol
[Molecular Weight]

372.38
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 100 mg/mL (270.01 mM)
Hazard InformationBack Directory
[Description]

Timapiprant, also known as OC000459, is a potent, selective and orally active CRTH2 antagonist. OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial. OC000459 inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. OC000459 treatment inhibited LAR and post-allergen increase in sputum eosinophils. OC000459 appears to inhibit allergic inflammation in asthma.
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