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Entolimod (CBLB-502), a recombinant protein is a toll-like receptor 5 (TLR5) agonist. Entolimod induces a cascade of TLR5-NF-κB signaling resulting in mobilization to the liver of various components of innate and adaptive immunity, followed by suppression of liver metastases and development of long-term antitumor immune memory[1][2]. | [References]
[1] Brackett CM, et al. Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E874-83. DOI:10.1073/pnas.1521359113
[2] Hua Yang, et al. The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism. Oncotarget . 2016 Jan 19;7(3):2936-50. DOI:10.18632/oncotarget.6500 |
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