ChemicalBook--->CAS DataBase List--->953836-17-4

953836-17-4

953836-17-4 Structure

953836-17-4 Structure
IdentificationBack Directory
[Name]

HUMAN HGF
[CAS]

NoCAS
[Synonyms]

HGF
HPTA
HGFB
F-TCF
RHHGF
HUMAN SF
HUMAN HGF
HGF, HUMAN
HUMAN HPTA
REC SF (HUMAN)
HUMAN HEPATOPOIETIN
HUMAN SCATTER FACTOR
RECOMBINANT HUMAN HGF
SCATTER FACTOR, HUMAN
Hepatopoietin-A (HPTA)
HEPATOPOIETIN A, HUMAN
HEPATOCYTE GROWTH FACTOR
REC SCATTER FACTOR (HUMAN)
REC HEPATOPOEITIN A (HUMAN)
HUMAN HEPATOCYTE GROWTH FACTOR
HEPATOCYTE GROWTH FACTOR, HUMAN
REC HEPATOCYTE GROWTH FACTOR (HUMAN)
Recombinant Human HGF Protein, His Tag
Hepatopoietin A, HGF, Scatter Factor
Recombinant Human HGF/HPTA Protein, His Tag
HEPATOCYTE GROWTH FACTOR, HUMAN, RECOMBINANT
HEPATOCYTE GROWTH FACTOR, HUMAN, RECOMBINANT, SPODOPTERA FRUGIPERDA
rec Scatter Factor (huMan), rec SF (huMan), rec Hepatopoeitin A (huMan)
[EINECS(EC#)]

214-275-1
[MDL Number]

MFCD00217422
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[form ]

powder
[biological source]

human
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/38
[Safety Statements ]

22-24/25-26
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Hepatocyte Growth Factor human has been used as a growth factor cocktail to suspend rat fibrogen/thrombin cells. It has also been used to study the tyrosine phosphorylation of MET (MET proto-oncogene, receptor tyrosine kinase) in myxofibrosarcoma cell line.
[General Description]

The HGF gene spans ~70 kb and consists of 18 exons interrupted by 17 introns. The organization of the human HGF gene is highly homologous to that of human plasminogen. HGF maps to the long arm of human chromosome 7, 7q21.1.
[Biochem/physiol Actions]

HGF is a multifunctional cytokine that promotes mitogenesis, migration, invasion, and morphogenesis. It is a potent mitogen, stimulating the growth of hepatocytes, renal tubular epithelial cells, epidermal keratinocytes, epidermal melanocytes, Mv1Lu (mink lung epithelial cells), and BALB/MK (mouse keratinocytes). HGF inhibits the growth of B6/F1 (mouse melanoma) cells, KB (human squamous carcinoma) cells, and HepG2 (human hepatoma) cells. HGF is the ligand for the tyrosine kinase receptor encoded by the met proto-oncogene.
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