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95385-38-9

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95385-38-9 Structure

95385-38-9 Structure
IdentificationBack Directory
[Name]

Tubulin polymerization-IN-57
[CAS]

95385-38-9
[Synonyms]

Tubulin polymerization-IN-57
Hazard InformationBack Directory
[Uses]

Tubulin polymerization-IN-57 (compound 5a) is a tubulin inhibitor and is an α-naphthoxy-substituted carbendazim (HY-13582) derivative. Tubulin polymerization-IN-57 induces mitotic arrest and inhibits cancer cell proliferation[1].
[References]

[1] Cano-González L et al. Structure-Based Optimization of Carbendazim-Derived Tubulin Polymerization Inhibitors through Alchemical Free Energy Calculations. J Chem Inf Model. 2023 Nov 27;63(22):7228-7238. DOI:10.1021/acs.jcim.3c01379
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