| Identification | Back Directory | [Name]
FPL 62129 | [CAS]
95445-79-7 | [Synonyms]
FPL 62129
3-methyl 5-(1-methylethyl) 4-(3-chloro-6-fluoro-2-(trifluoromethyl)phenyl)-2-(fluoromethyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate | [Molecular Formula]
C20H19ClF5NO4 | [MOL File]
95445-79-7.mol | [Molecular Weight]
467.814 |
| Hazard Information | Back Directory | [Description]
FPL-62129 is a calcium channel antagonist for the treatment of hypertension and myocardia ischemia. FPL-62129 reduced blood pressure without altering heart rate. FPL 62129 showed marked activity at the sinus node and to a lesser extent at the atrioventricular node. Unlike nifedipine, FPL 62129 demonstrates vasodilator and direct decelerator properties over the same dose range, which accounts for its ability to lower blood pressure without causing reflex tachycardia in this model. | [Uses]
FPL 62129 is an antagonist for calcium channel. FPL 62129 reduces blood pressure and total peripheral resistance, increases the cardiac contractility and cardiac output in anarsthetised beagle model. FPL 62129 also serves as a vasodilator and a direct decelerator[1]. | [References]
[1] Humphries RG, et al., Cardiovascular profile of FPL 62129, a novel dihydropyridine calcium channel blocker, in anaesthetised dogs: a comparison with nifedipine. J Cardiovasc Pharmacol. 1988 Mar;11(3):332-8. DOI:10.1097/00005344-198803000-00011 |
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