| Identification | Back Directory | [Name]
10Panx | [CAS]
955091-53-9 | [Synonyms]
10Panx
Trp Arg Gln Ala Ala Phe Val Asp Ser Tyr
L-Tyrosine, L-tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl- | [Molecular Formula]
C58H79N15O16 | [MDL Number]
MFCD09842372 | [MOL File]
955091-53-9.mol | [Molecular Weight]
1242.36 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥124.2 mg/mL in DMSO; insoluble in EtOH; ≥4.26 mg/mL in H2O with ultrasonic | [form ]
solid | [pka]
3.05±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr |
| Hazard Information | Back Directory | [Uses]
L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosine is a connexin mimetic peptide that inhibits pannexin-1 gap junctions. | [Biological Activity]
10panx is a mimetic inhibitory peptide of panx1, which is a mammalian protein ectopically expressed to function as a hemi-channel, that readily and reversibly inhibits the panx1 currents. 10panx has attracted increasing attention as it allows scientists readily and reliably to examine inhibition of panx1 in cells where efficient and consistent delivery of sirna is highly difficult. according to results of multiple previous studies, 10panx selectively inhibits p2x7r-induced dye uptake without altering other aspects of r2x7r activation and atp-evoked membrane currents, constitutive dye-uptake and hemichannel-like currents that are induced by the overexpression of panx1, and atp-mediated il-1β release.pablo pelegrin and annmarie surprenant. pannexin-1 mediates large pore formation and interleukin-1β release by the atp-gated p2x7 receptor. the embo journal (2006) 25, 5071-5082 | [in vivo]
10Panx (300 μM; intrathecal injection; single dose; 1 h pretreatment) completely abolished NMDA- and BzATP-induced mechanical hyperalgesia and C-reflex wind-up potentiation in a neuropathic rat model[3]. | [storage]
Store at -20°C |
|
|