| Identification | Back Directory | [Name]
N6-(P-AMINOBENZYL)ADENOSINE | [CAS]
95523-13-0 | [Synonyms]
N6-(P-AMINOBENZYL)ADENOSINE
N(sup 6)(p-aminobenzyl)adenosine
N-[(4-Aminophenyl)methyl]adenosine
[125I]-N6-(4-Aminobenzyl)adenosine
Adenosine, N-[(4-aminophenyl)methyl]-
N [(4 Aminophenyl)methyl]adenosine,N[(4Aminophenyl)methyl]adenosine | [Molecular Formula]
C17H20N6O4 | [MDL Number]
MFCD00083216 | [MOL File]
95523-13-0.mol | [Molecular Weight]
372.38 |
| Chemical Properties | Back Directory | [Boiling point ]
749.0±70.0 °C(Predicted) | [density ]
1.71±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.12±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor, with Ki of 29 nM for Rat ecto-5′-Nucleotidase.
IC50 value: 29.0 ± 1.7 nM (Ki)
Target: Adenosine Receptor | [References]
[1] Bhattarai S, et al. α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58(15):6248-63. DOI:10.1021/acs.jmedchem.5b00802
[2] Chen JB, et al. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. 2011 Aug 1;6(8):1390-400. DOI:10.1002/cmdc.201100126
[3] Zhu Z, et al. Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem. 2008 Apr 1;16(7):3848-65. DOI:10.1016/j.bmc.2008.01.044 |
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