| Identification | Back Directory | [Name]
Avenanthramide-C methyl ester | [CAS]
955382-52-2 | [Synonyms]
IUZHCICFVDHVMC-XVNBXDOJSA-N
Avenanthramide-C methyl ester
Avenanthramide-C methyl ester Exclusive
Avenanthramide C methyl ester,AvenanthramideC methyl ester
methyl 2-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-5-hydroxybenzoate
Benzoic acid, 2-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]amino]-5-hydroxy-, methyl ester | [Molecular Formula]
C17H15NO6 | [MDL Number]
MFCD18382082 | [MOL File]
955382-52-2.mol | [Molecular Weight]
329.3 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM).1 Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells. 1 | [References]
1. Guo, W., Wise, M.L., Collins, F.W., et al. Avenanthramides, polyphenols from oats, inhibit IL-1β-induced NF-κB activation in endothelial cells Free Radic. Biol. Med. 44(3),415-429(2008). |
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