| Identification | Back Directory | [Name]
PF 04279405 | [CAS]
955881-01-3 | [Synonyms]
PF 04279405
PF-04279405
4-[4-(1-Azetidinylcarbonyl)-3-fluorophenoxy]-2,3-dihydro-2,2-dimethyl-N-(1-methyl-1H-pyrazol-3-yl)-6-benzofurancarboxamide
6-Benzofurancarboxamide, 4-[4-(1-azetidinylcarbonyl)-3-fluorophenoxy]-2,3-dihydro-2,2-dimethyl-N-(1-methyl-1H-pyrazol-3-yl)- | [Molecular Formula]
C25H25FN4O4 | [MDL Number]
MFCD28100805 | [MOL File]
955881-01-3.mol | [Molecular Weight]
464.49 |
| Hazard Information | Back Directory | [Uses]
PF-04279405 is a potent and full-acting glucokinase (GK) agonist (EC50=23 nM). Glucokinase (GK) is an enzyme responsible for the conversion of glucose to glucose-6-phosphate and plays a key role in maintaining blood glucose homeostasis. PF-04279405 can be used in the research of type 2 diabetes[1]. | [References]
[1] Pettersen, et al. The relationship of glucokinase activator–induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies. Toxicologic Pathology 42.4 (2014): 696-708. DOI:10.1177/0192623314526006 |
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