| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxamide, N-[(4-ethylphenyl)methyl]-3,5-dimethyl-1-(phenylmethyl)-N-(3-pyridinylmethyl)- | [CAS]
956935-02-7 | [Synonyms]
1H-Pyrazole-4-carboxamide, N-[(4-ethylphenyl)methyl]-3,5-dimethyl-1-(phenylmethyl)-N-(3-pyridinylmethyl)- | [Molecular Formula]
C28H30N4O | [MOL File]
956935-02-7.mol | [Molecular Weight]
438.56 |
| Hazard Information | Back Directory | [Uses]
Ena15 is an ALKBH5 inhibitor. Ena15 enhances the demethylase activity of FTO. Ena15 increases m6A RNA level, and stabilizes FOXM1 mRNA. Ena15 suppresses the growth activity of glioblastoma multiforme[1]. | [References]
[1] Takahashi H, et al. Discovery of two novel ALKBH5 selective inhibitors that exhibit uncompetitive or competitive type and suppress the growth activity of glioblastoma multiforme. Chem Biol Drug Des. 2022 Jul;100(1):1-12. DOI:10.1111/cbdd.14051 |
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