| Identification | Back Directory | [Name]
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-2-[(3,4,8,8-tetramethyl-2-oxo-9,10-dihydropyrano[2,3-h]chromen-5-yl)oxy]acetamide | [CAS]
956965-61-0 | [Synonyms]
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-2-[(3,4,8,8-tetramethyl-2-oxo-9,10-dihydropyrano[2,3-h]chromen-5-yl)oxy]acetamide | [Molecular Formula]
C29H32N2O6 | [MOL File]
956965-61-0.mol | [Molecular Weight]
504.57 |
| Hazard Information | Back Directory | [Description]
NPD4928 enhanced the sensitivity of various cancer cells to GPX4 inhibitors, suggesting that the combination might have therapeutic potential via the induction of ferroptosis. | [Uses]
NPD4928, a GPX4 inhibitor, enhances RSL3 (HY-100218A)-dependent ferroptosis. NPD4928 binds to ferroptosis suppressor protein 1 (FSP1) and inhibits its enzymatic activity[1]. | [References]
[1] Hiromasa Yoshioka, et al. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1). ACS Chem Biol. 2022 Feb 18;17(2):483-491. DOI:10.1021/acschembio.2c00028 |
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