| Identification | Back Directory | [Name]
(8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride | [CAS]
957116-20-0 | [Synonyms]
CS-549
MK3207 HCl
MK-3207 HCl salt
MK 3207 hydrochloride
MK3207 MK-3207 hydrochloride HCL
MK3207 HYDROCHLORIDE;MK 3207 HYDROCHLORIDE;MK-3207
2-((R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide hydrochloride
6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, hydrochloride
(8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride
(8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride USP/EP/BP | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C31H29F2N5O3.HCl | [MDL Number]
MFCD16038934 | [MOL File]
957116-20-0.mol | [Molecular Weight]
594.051 |
| Hazard Information | Back Directory | [Uses]
MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3. | [Biological Activity]
MK-3207 HCl is a potent CGRP receptor antagonist with IC50 and Ki of 0.12 nM and 0.022 nM, respectively, with high selectivity for human AM1, AM2, CTR, and AMY3. Phase 2. | [in vivo]
MK-3207 is CNS-penetrant and therefore significantly engaging central receptors. After an oral dose of 10 mg/kg MK-3207, the CSF/plasma ratio is 2 to 3%[1]. | [References]
[1] Salvatore CA, et al. Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60. DOI:10.1124/jpet.109.163816 |
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