| Identification | Back Directory | [Name]
3,6-dibroMopyrazine-2-carboxylic acid | [CAS]
957230-68-1 | [Synonyms]
3,6-dibromo-2-Pyrazinecarboxylic acid
3,6-dibroMopyrazine-2-carboxylic acid
2-Pyrazinecarboxylic acid, 3,6-dibromo-
2-Pyrazinamine, 5-bromo-3-(bromomethyl)-,hydrobromide (1:1) | [Molecular Formula]
C5H2Br2N2O2 | [MDL Number]
MFCD13193674 | [MOL File]
957230-68-1.mol | [Molecular Weight]
281.89 |
| Chemical Properties | Back Directory | [Boiling point ]
368.7±42.0 °C(Predicted) | [density ]
2.333±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
1.17±0.10(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3,6-dibromopyrazine-2-carboxylic acid from methyl 3,6-dibromopyrazine-2-carboxylate: a solution of LiOH (121 mg, 5.07 mmol) in water (1 mL) was added slowly and dropwise at 0 °C to methyl 3,6-dibromopyrazine-2-carboxylate (500 mg, 1.67 mmol) dissolved in a 1:1 THF/water (8 mL) solution. The reaction mixture was stirred continuously at 0 °C for 45 min. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in a mixed system of dichloromethane (DCM) and 1N aqueous hydrochloric acid. The organic layer was separated and the aqueous phase was extracted twice with DCM. All organic extracts were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give 350 mg (74% yield) of a cream-colored solid product. Mass spectrometry (MS) analysis showed: m/z (ES) 282 (M + H)+. | [References]
[1] Patent: US2011/59118, 2011, A1. Location in patent: Page/Page column 57
[2] Patent: US2009/286798, 2009, A1. Location in patent: Page/Page column 26
[3] Patent: US2011/118269, 2011, A1. Location in patent: Page/Page column 13
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 6, p. 2266 - 2270
[5] Patent: WO2007/131991, 2007, A1. Location in patent: Page/Page column 47-48 |
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