| Hazard Information | Back Directory | [Description]
TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor for the treatment of type 2 diabetes. TP0438836 showed IC50 values 28nM and 7 nM for hSGLT1 and hSGLT2 resepctively. | [Uses]
TP0438836 (compound 30b) is a SGLT1 inhibitor, with IC50 values ??of 28 nM and 7 nM for hSGLT1 and hSGLT2, respectively. TP0438836 can be used in diabetes research[1]. | [IC 50]
hSGLT1: 28 nM (IC50); hSGLT2: 7 nM (IC50) | [References]
[1] Kuroda S, et al. Discovery of a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor (TP0438836) for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3534-3539. DOI:10.1016/j.bmcl.2018.09.035 |
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