| Identification | Back Directory | [Name]
1-N-CBZ-3-HYDROXY-PIPERIDINE | [CAS]
95798-22-4 | [Synonyms]
BUTTPARK 99\04-58
N-Cbz-3-hydroxypiperidine
1-Cbz-3-hydroxy-piperidine
1-N-CBZ-3-HYDROXY-PIPERIDINE
1-BENZYLOXYCARBONYL-3-HYDROXYPIPERIDINE
1-N-CBZ-3-HYDROXY-PIPERIDINE ISO 9001：2015 REACH
3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
BENZYL 3-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
1-Piperidinecarboxylic acid, 3-hydroxy-, phenylMethyl ester | [Molecular Formula]
C13H17NO3 | [MDL Number]
MFCD03839903 | [MOL File]
95798-22-4.mol | [Molecular Weight]
235.28 |
| Chemical Properties | Back Directory | [Boiling point ]
196 °C | [density ]
1.220±0.06 g/cm3(Predicted) | [storage temp. ]
Store at room temperature | [pka]
14.72±0.20(Predicted) | [Appearance]
Light yellow to yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of N-Benzyloxycarbonyl-3-hydroxypiperidine from 3-hydroxypiperidine hydrochloride and benzyl chloroformate: Na2CO3 (23.10 g, 218 mmol) was added to a solution of THF/H2O (50 mL/50 mL) containing 3-hydroxypiperidine hydrochloride (10.00 g, 73 mmol). Benzyl chloroformate (14.90 g, 87 mmol) was added dropwise at room temperature and the reaction mixture was stirred for 5 hours. After the reaction was completed, the mixture was extracted with EtOAc (100 mL x 3). The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated. The resulting residue was purified by silica gel column chromatography with EtOAc/petroleum ether (1/100~1/4, v/v) as eluent to afford N-benzyloxycarbonyl-3-hydroxypiperidine (16.50 g, 96%) as a colorless oil. detected by TLC: Rf = 0.65 (silica gel plate, EtOAc/petroleum ether = 1/1, v/v). | [References]
[1] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 44; 45
[2] Patent: WO2014/68527, 2014, A1. Location in patent: Page/Page column 75; 15 |
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