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Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity[1][2][3]. | [References]
[1] M Ortigao, et al. Momordin II, a ribosome inactivating protein from Momordica balsamina, is homologous to other plant proteins. Nucleic Acids Res DOI:10.1093/nar/20.17.4662
[2] P Valbonesi, et al. Preparation of highly purified momordin II without ribonuclease activity. Life Sci. 1999;65(14):1485-91. DOI:10.1016/s0024-3205(99)00389-6
[3] Hung-Tse Huang, et al. Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis. Nat Prod Res. 2021 Aug;35(16):2707-2714. DOI:10.1080/14786419.2019.1666383 |
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