| Identification | Back Directory | [Name]
2,4(1H,3H)-Quinazolinedione, 7-iodo- | [CAS]
959236-72-7 | [Synonyms]
7-Iodoquinazoline-2,4(1H,3H)
7-iodo-1H-quinazoline-2,4-dione
7-Iodo-2,4(1H,3H)-quinazolinedione
2,4(1H,3H)-Quinazolinedione, 7-iodo- | [Molecular Formula]
C8H5IN2O2 | [MDL Number]
MFCD09954830 | [MOL File]
959236-72-7.mol | [Molecular Weight]
288.04 |
| Hazard Information | Back Directory | [Synthesis]
2-(Ethylthio)-7-iodoquinazolin-4(3H)-one (10.8 g, 32.5 mmol) was used as a raw material, which was dissolved in ethanol (40 mL), followed by the addition of 6N hydrochloric acid (40 mL). The reaction mixture was heated to reflux at 80 °C overnight, and upon completion of the reaction and cooling to room temperature, a large amount of white precipitate was observed to be generated. The precipitate was collected by filtration to afford the off-white solid product 7-iodoquinazoline-2,4(1H,3H)-dione (8.97 g, 96% yield). Mass spectrum (ESI) m/z 289.0. | [References]
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 2, p. 897 - 910
[2] Patent: WO2008/86462, 2008, A2. Location in patent: Page/Page column 66 |
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