959860-49-2

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959860-49-2 Structure

Identification	Back Directory
[Name] Guajadial
[CAS] 959860-49-2
[Synonyms] Guajadial Guava dialdehyde PubChem ID: 46197930 Benzo[b]cyclobuta[5,6]cyclonona[1,2-e]pyran-6,8-dicarboxaldehyde, 1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydro-7,9-dihydroxy-2,2,4a-trimethyl-13-methylene-10-phenyl-, (2aS,4aS,10S,10aR,13aR)-
[Molecular Formula] C30H34O5
[MDL Number] MFCD20260726
[MOL File] 959860-49-2.mol
[Molecular Weight] 474.59

Hazard Information	Back Directory
[Uses] Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves[1][2].
[References] [1] Bazioli JM, et al. Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.). Molecules. 2020 Mar 27;25(7):1525. DOI:10.3390/molecules25071525 [2] Li Y, et al. Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and suppressing the PI3K/Akt pathway in drug-resistant breast cancer cells. Chem Biol Interact. 2019 May 25;305:98-104. DOI:10.1016/j.cbi.2019.03.032

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