| Identification | Back Directory | [Name]
LIPID A, DIPHOSPHORYL FROM ESCHERICHIA COLI F-583 (RD MUTANT) | [CAS]
95991-05-2 | [Synonyms]
lipid A, diphosphoryl
LIPID A, DIPHOSPHORYL FROM SALMONELLA*MI NNESOTA RE-
LIPID A, DIPHOSPHORYL FROM ESCHERICHIA COLI F-583 (RD MUTANT)
LIPID A, DIPHOSPHORYL FROM SALMONELLA MINNESOTA RE-595 (R MUTANTS)
lipid a, diphosphoryl from salmonella enterica serotype minnesota re 595 (re mutant)
2-deoxy-6-O-<2-deoxy-2-<(R)-3-dodecanoyloxytetradecanoylamino>-3-O-<(R)-3-tetradecanoyloxytetradecanoyl>-β-D-glucopyranosyl>-3-O-<(R)-3-hydroxytetradecanoyl>-2-<(R)-3-hydroxytetradecanoylamino>-α-D-glucopyranose 1,4'-bis(phosphate)
α-D-Glucopyranose, 2-deoxy-6-O-[2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-β-D-glucopyranosyl]-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-, 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate]
α-D-Glucopyranose, 2-deoxy-6-O-[2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-β-D-glucopyranosyl]-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-, 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate] | [Molecular Formula]
C94H178N2O25P2 | [MDL Number]
MFCD07369021 | [MOL File]
95991-05-2.mol | [Molecular Weight]
1798.37 |
| Chemical Properties | Back Directory | [density ]
1.13±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
lyophilized powder | [pka]
1.73±0.10(Predicted) | [biological source]
Escherichia coli (F583 Rd mutant) |
| Hazard Information | Back Directory | [Uses]
Lipid A, diphosphoryl from?Escherichia coli?F583 (Rd mutant) has been used:
- to study the effect of various lipid A molecules on lung pericyte proliferation in vitro
- to test on THP-1 and J774A.1 cells for neopterin and nitrite formation respectively
- as lipopolysaccharides (LPS) derivatives in binding experiments
- to stimulate the spleen cells and as a mitogen stimulation for toll like receptor 4 (TLR4)
| [General Description]
Lipid A is the fundamental structure of lipopolysaccharides (LPS), present in bacteria. | [Biochem/physiol Actions]
Lipid A is mainly essential for the robust immunostimulatory activities of lipopolysaccharides (LPS) in human. Lipid A is the hydrophobic domain of LPS helps in anchoring LPS to the plasma membrane of bacteria. It is immunologically active and an important constituent of LPS recognised by immune system. |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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