| Identification | Back Directory | [Name]
H-ASN-ASN-TRP-ASN-ASN-OH TRIFLUOROACETATE | [CAS]
960129-66-2 | [Synonyms]
EDF
BCDFII
IL-5 from mouse
H-Asn-Asn-Trp-Asn-Asn-OH
EXTRACELLULAR DEATH FACTOR
Extracellular Death Factor, EDF
H-ASN-ASN-TRP-ASN-ASN-OH TRIFLUOROACETATE
Extracellular Death Factor trifluoroacetate salt
Extracellular death factor (synthetic Escherichia coli)
L-Asparaginyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-L-asparagine
L-Asparagine,L-asparaginyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-
Extracellular Death Factor trifluoroacetate salt H-Asn-Asn-Trp-Asn-Asn-OH trifluoroacetate salt
(2S)-4-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoic acid | [Molecular Formula]
C27H36N10O10 | [MDL Number]
MFCD11975011 | [MOL File]
960129-66-2.mol | [Molecular Weight]
660.64 |
| Chemical Properties | Back Directory | [Boiling point ]
1452.5±65.0 °C(Predicted) | [density ]
1.493±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble; Water: Soluble | [form ]
lyophilized | [pka]
3.13±0.10(Predicted) | [color ]
colorless | [Sequence]
H-Asn-Asn-Trp-Asn-Asn-OH |
| Hazard Information | Back Directory | [Uses]
Extracellular Death Factor (ECF) is the dramatic name given to an interesting linear pentapeptide produced by E. coli, first identified by Engelberg-Kulka and colleagues in 2007 and published in Science. ECF acts as a quorum sensing agent, regulating bacterial cell density by balancing the levels of toxin and antitoxin via mazEF-mediated cell death genes. | [General Description]
IL-5 (interleukin 5) is a Th2 (T helper 2) cytokine that is predominantly produced by T lymphocytes, and to a lower extent by mast cells, type 2 innate lymphoid (ILC2) cells, and eosinophils.
Recombinant murine IL-5 is a 26.2kDa disulfide-linked homodimeric protein containing two 113 amino acid chains. | [Biochem/physiol Actions]
IL-5 (interleukin 5) was initially identified as a stimulant of antibody production by activated B cells. It has recently been shown to be a key factor in eosinophil differentiation and proliferation. It is also implicated in the pathogenesis of asthma, atopy, hypereosinophilic syndromes, and parasitic infections. In distal lung, IL-5 recruits eosinophils and modulates inflammatory or immune cells in the microenvironment, thus, promoting lung metastasis in cancer. |
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