| Identification | Back Directory | [Name]
Silvestrol aglycone | [CAS]
960365-65-5 | [Synonyms]
Silvestrol aglycone
(1R,2R,3S,3aR,8bS)-methyl 1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]-cyclopenta[d]furan-2-carboxylate
(1R,2R,3S,3aR,8bS)-2,3,3a,8b-Tetrahydro-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester
1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 2,3,3a,8b-tetrahydro-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)- | [Molecular Formula]
C27H26O8 | [MOL File]
960365-65-5.mol | [Molecular Weight]
478.49 |
| Chemical Properties | Back Directory | [Melting point ]
127-129℃ | [Boiling point ]
645.4±55.0 °C(Predicted) | [density ]
1.408 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 106 mg/mL (221.53 mM) | [form ]
Solid | [pka]
8.93±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity[1]. | [storage]
Store at -20°C | [References]
[1] Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. DOI:10.1021/jm3011542 |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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Musechem
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+1-800-259-7612 |
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www.musechem.com |
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BOC Sciences
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16314854226 |
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