| Identification | Back Directory | [Name]
1-Benzotriazolyl Diethyl Phosphate | [CAS]
96338-11-3 | [Synonyms]
1-Benzotriazolyl Diethyl Phosphate
benzotriazol-1-yl diethyl phosphate
Phosphoric acid, 1H-benzotriazol-1-yl diethyl ester | [Molecular Formula]
C10H14N3O4P | [MOL File]
96338-11-3.mol | [Molecular Weight]
271.21 |
| Chemical Properties | Back Directory | [Boiling point ]
350.6±25.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [solubility ]
sol MeCN, DMF, EtOAc, CH2Cl2, THF | [pka]
-0.80±0.30(Predicted) |
| Hazard Information | Back Directory | [Uses]
1-Benzotriazolyl Diethyl Phosphate is a coupling reagent for amides and peptide synthesis. | [Preparation]
1-Benzotriazolyl Diethyl Phosphate can be prepared by reaction of diethyl chlorophosphate (1 equiv) and 1- hydroxybenzotriazole (1 equiv) in the presence of triethylamine (1 equiv) in dry THF at 0 °C for 30 min, with 90-95% yields. | [storage]
1-Benzotriazolyl Diethyl Phosphate can be stored in a desiccator with drierite at 4 °C for several weeks without decomposition. Distillation in vacuo leads to decomposition. | [Purification Methods]
by filtration through a short column of silica gel or cellulose. |
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