| Identification | Back Directory | [Name]
GLY-ARG-GLY-ASP-SER | [CAS]
96426-21-0 | [Synonyms]
GRGDS
GRGDS 1/2ACOH 2H2O
GLY-ARG-GLY-ASP-SER
H-GLY-ARG-GLY-ASP-SER-OH
Gly-Arg-Gly-Asp-Ser (TFA)
GRGDS, fibrinogen fragment
GLY-ARG-GLY-ASP-SER ACETATE
GLY-ARG-GLY-ASP-SER 1/2ACOH 2H2O
Gly-Arg-Gly-Asp-Ser >=97% (HPLC)
H-Gly-Arg-Gly-Asp-Ser-OH TFA salt
glycyl-arginyl-glycyl-aspartyl-serine
GRGDS, FIBRONECTIN ATTACHMENT PEPTIDE
L-Serine, glycyl-L-arginylglycyl-L-a-aspartyl-
L-Serine, glycyl-L-arginylglycyl-L-α-aspartyl-
Glycyl-L-Arginylglycyl-L-alpha-Aspartyl-L-Serine
H-Gly-Arg-Gly-Asp-Ser-OH - CAS 96426-21-0 - Calbiochem
L-Serine, N-(N-(N-(N2-glycyl-L-arginyl)glycyl)-L-alpha-aspartyl)-
(S)-3-{2-[(S)-2-(2-Amino-acetylamino)-5-guanidino-pentanoylamino]-acetylamino}-N-((S)-1-carboxy-2-hydroxy-ethyl)-succinamic acid
(6S,12S,15S)-1-aMino-6-(2-aMinoacetaMido)-12-(carboxyMethyl)-15-(hydroxyMethyl)-1-iMino-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oic acid | [Molecular Formula]
C17H30N8O9 | [MDL Number]
MFCD00076459 | [MOL File]
96426-21-0.mol | [Molecular Weight]
490.47 |
| Chemical Properties | Back Directory | [density ]
1.66±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO : 100 mg/mL (203.89 mM);Water : 33.33 mg/mL (67.96 mM) | [form ]
White to off-white lyophilized solid | [pka]
2.85±0.10(Predicted) | [color ]
White to off-white | [Sequence]
H-Gly-Arg-Gly-Asp-Ser-OH | [InChIKey]
RGNVSYKVCGAEHK-GUBZILKMSA-N | [SMILES]
NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O |
| Hazard Information | Back Directory | [Uses]
Gly-Arg-Gly-Asp-Ser has been used-
- as an antigen to determine whether integrin α4 or α5 hinders the adhesion of day 3 postirradiation thymocytes to thymic epithelial cells, in mice
- for the treatment of collagen IV-coated dishes to study the role of integrins α1, αv, β1, and β3 in Sca-1+ progenitor cell differentiation into SMCs (smooth muscle cells)
- as a blocking peptide for the pre-incubation of Nisseria meningitides strains, to perform blocking experiments to study the interactions between these bacterial strains and fibronectin
- for the pre-treatment of EL-4 cells infected by AdCMV-GFP (cytomegalovirus-green fluorescent protein), to study whether interaction with cellular integrins is essential for the transduction of adenovirus
| [General Description]
Gly-Arg-Gly-Asp-Ser peptide sequence is identical to the cell-binding region of fibronectin protein. Arg-Gly-Asp (RGD) region is found in various proteins, and is crucial for facilitating cell-adhesive activity. | [Biochem/physiol Actions]
Antagonist of integrin function |
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