| Identification | Back Directory | [Name]
4-Pyrimidinamine, 2-fluoro- (9CI) | [CAS]
96548-91-3 | [Synonyms]
2-fluoropyrimidin-4-amine
4-amino-2-fluoropyrimidine
2-FLUORO-4-PYRIMIDINEAMINE
4-Pyrimidinamine, 2-fluoro-
4-Pyrimidinamine, 2-fluoro- (9CI) | [Molecular Formula]
C4H4FN3 | [MDL Number]
MFCD00769380 | [MOL File]
96548-91-3.mol | [Molecular Weight]
113.09 |
| Chemical Properties | Back Directory | [Boiling point ]
324.9±34.0 °C(Predicted) | [density ]
1.372±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
2.58±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
General procedure: pre-step A Synthesis of 2-fluoro-4-pyrimidinamine
A mixed solution of 2,4-difluoropyrimidine (200 mg, 1.723 mmol) with ammonia (1600 μL, 22.18 mmol) in 1,4-dioxane (2 mL) was stirred at -21°C (salt-ice bath) for 5 min. Subsequently, methanol (1 mL) was added to the reaction mixture and the crude product was purified by reversed-phase high-performance liquid chromatography (RP-HPLC) to afford 2-fluoro-4-pyrimidinamine (94 mg, 0.831 mmol, 48% yield) as a white solid. Mass spectrum (electrospray positive ion mode) m/z 114.1 ([M+H]+). | [References]
[1] Patent: US2013/345120, 2013, A1. Location in patent: Page/Page column
[2] Patent: US8901119, 2014, B2. Location in patent: Page/Page column |
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