| Identification | Back Directory | [Name]
(+/-)-MCN 5652 | [CAS]
96795-89-0 | [Synonyms]
(-)-McN-5652Z
(-)-McN-5652-Z
(+/-)-MCN 5652
trans-McN-5652
(+/-)-MCN 5652
1,2,3,5,6,10bβ-Hexahydro-6α-[4-(methylthio)phenyl]pyrrolo[2,1-a]isoquinoline
(6S)-1,2,3,5,6,10bβ-Hexahydro-6β-(4-methylthiophenyl)pyrrolo[2,1-a]isoquinoline
trans-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline
(6R,10bS)-6-(4-methylsulfanylphenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline
(6R,10bS)-rel-1,2,3,5,6,10b-Hexahydro-6-[4-(methylthio)phenyl]-pyrrolo[2,1-a]isoquinoline
Pyrrolo[2,1-a]isoquinoline, 1,2,3,5,6,10b-hexahydro-6-[4-(methylthio)phenyl]-, (6R,10bS)-rel-
rel-(6R*,10bS*)-6α*-[4-(Methylthio)phenyl]-1,2,3,5,6,10bβ*-hexahydropyrrolo[2,1-a]isoquinoline | [Molecular Formula]
C19H21NS | [MDL Number]
MFCD09753376 | [MOL File]
96795-89-0.mol | [Molecular Weight]
295.44 |
| Hazard Information | Back Directory | [Uses]
McN 5652, (+/-) is a 5-HT uptake inhibitor. | [Definition]
ChEBI: (6R,10bS)-6-[4-(methylthio)phenyl]-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline is a member of isoquinolines. | [Biological Activity]
Potent, high affinity serotonin re-uptake inhibitor that is selective in vivo . In vitro, displays moderate selectivity over noradrenalin and dopamine re-uptake (K i values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo following oral administration. Biological activity resides predominantly in (+)-enantiomer. |
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