| Identification | Back Directory | [Name]
INDATRALINE HYDROCHLORIDE | [CAS]
96850-13-4 | [Synonyms]
LU 19-005
EOS 60004
INDATRALINE HYDROCHLORIDE
3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine
INDATRALINE HCL (POTENT INHIBITOR OF DOP AMINENOREPINEPHRINE AND SE
(+/-)-TRANS-3-(3,4-DICHLOROPHENYL)-N-METHYL-1-INDANAMINE HYDROCHLORIDE
Lu 19-005, (±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride
rel-(1R,3S)-3-(3,4-Dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine hydrochloride
(1R,3S)-REL-3-(3,4-DICHLOROPHENYL)-2,3-DIHYDRO-N-METHYL-1H-INDEN-1-AMINE HYDROCHLORIDE | [Molecular Formula]
C16H16Cl3N | [MDL Number]
MFCD00083178 | [MOL File]
96850-13-4.mol | [Molecular Weight]
328.66 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
0.1 M HCl: 1 mg/mL | [form ]
solid | [color ]
white | [Water Solubility ]
H2O: 2mg/mL | [InChI]
1S/C16H15Cl2N.ClH/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10;/h2-8,13,16,19H,9H2,1H3;1H/t13-,16+;/m0./s1 | [InChIKey]
QICQDZXGZOVTEF-MELYUZJYSA-N | [SMILES]
Cl.CN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13 |
| Safety Data | Back Directory | [Hazard Codes ]
N | [Risk Statements ]
50/53 | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 9/PG 3 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Uses]
Indatraline hydrochloride has been used:
- as a competitive inhibitor of 3H-dopamine ([3H]DA) to study its effects on trans-activator of transcription (Tat) protein on cocaine-induced inhibition of uptake of [3H]DA
- as a dopamine transport blocker to study its effects on trace amine-associated receptor 1 (TAAR1)-transfected mice cells
- as a nonselective monoamine transport inhibitor to study its anti-angiogenic activities in glioblastoma multiforme (GBM)
| [Uses]
Indatraline Hydrochloride?inhibits the synaptosomal uptake of 3,4-dihydroxyphenylethylamine (dopamine, DA), noradrenaline (NA), and 5-hydroxytryptamine (5-HT, serotonin). | [Biochem/physiol Actions]
Indatraline is a non-selective monoamine transport inhibitor. It inhibits the reuptake of neurotransmitters, such as serotonin, norepinephrine and dopamine. It exhibits anti-depressant and anti-angiogenic effects. Indatraline also plays a role in inducing autophagy. | [in vivo]
Indatraline (2 μM) hydrochloride inhibits neointimal accumulation of smooth muscle cells[1]. | [storage]
Desiccate at RT |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|