| Identification | Back Directory | [Name]
INDATRALINE HYDROCHLORIDE | [CAS]
96850-13-4 | [Synonyms]
LU 19-005
EOS 60004
INDATRALINE HYDROCHLORIDE
3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine
INDATRALINE HCL (POTENT INHIBITOR OF DOP AMINENOREPINEPHRINE AND SE
(+/-)-TRANS-3-(3,4-DICHLOROPHENYL)-N-METHYL-1-INDANAMINE HYDROCHLORIDE
Lu 19-005, (±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride
rel-(1R,3S)-3-(3,4-Dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine hydrochloride
(1R,3S)-REL-3-(3,4-DICHLOROPHENYL)-2,3-DIHYDRO-N-METHYL-1H-INDEN-1-AMINE HYDROCHLORIDE | [Molecular Formula]
C16H16Cl3N | [MDL Number]
MFCD00083178 | [MOL File]
96850-13-4.mol | [Molecular Weight]
328.66 |
| Hazard Information | Back Directory | [Uses]
Indatraline hydrochloride has been used:
- as a competitive inhibitor of 3H-dopamine ([3H]DA) to study its effects on trans-activator of transcription (Tat) protein on cocaine-induced inhibition of uptake of [3H]DA
- as a dopamine transport blocker to study its effects on trace amine-associated receptor 1 (TAAR1)-transfected mice cells
- as a nonselective monoamine transport inhibitor to study its anti-angiogenic activities in glioblastoma multiforme (GBM)
| [Uses]
Indatraline Hydrochloride?inhibits the synaptosomal uptake of 3,4-dihydroxyphenylethylamine (dopamine, DA), noradrenaline (NA), and 5-hydroxytryptamine (5-HT, serotonin). | [Biochem/physiol Actions]
Indatraline is a non-selective monoamine transport inhibitor. It inhibits the reuptake of neurotransmitters, such as serotonin, norepinephrine and dopamine. It exhibits anti-depressant and anti-angiogenic effects. Indatraline also plays a role in inducing autophagy. | [storage]
Desiccate at RT |
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Sigma-Aldrich
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Energy Chemical
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http://www.energy-chemical.com |
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