| Identification | Back Directory | [Name]
DL-GLUTAMIC-2,4,4-D3 ACID | [CAS]
96927-56-9 | [Synonyms]
DL-GlutaMic-d3 Acid
DL-Glutamic acid-d3
DL Deuteroglutamate D3
DL-GLUTAMIC-2,4,4-D3 ACID
DL-Glutamic Acid-2,2,4-D3
DL-GLUTAMIC ACID (2,4,4-D3)
2-Aminopentanedioic acid-2,4,4-d3
(2R,S)-<2,4,4-(2)H3>-glutamic acid
DL-GLUTAMIC-2,4,4-D3 ACID USP/EP/BP | [Molecular Formula]
C5H9NO4 | [MDL Number]
MFCD00144175 | [MOL File]
96927-56-9.mol | [Molecular Weight]
147.13 |
| Chemical Properties | Back Directory | [Melting point ]
185 °C (dec)(lit.) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly, Heated), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Appearance]
white solid | [CAS Number Unlabeled]
617-65-2 |
| Hazard Information | Back Directory | [Description]
Glutamic acid together with its γ-monoamide – glutamine – makes up about a third of all free amino acids in blood plasma, its content in body proteins is 20-25 %. In the blood, glutamic acid maintains pH balance, binds excess ammonia, turning into glutamine, transports it to the site of detoxification, and serves as a reserve of amino groups. Glutamic acid acts as an excitatory neurotransmitter and agonist of all subtypes of glutamate receptors (metabotropic, kainate, NMDA and AMPA), and is also a precursor of gamma-aminobutyric acid (GABA). Glutamic acid has an immunomodulatory effect and affects many metabolic processes. | [Uses]
DL-Glutamic acid-d3 is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability[1]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110 |
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