| Identification | Back Directory | [Name]
4-Fluoro-5-methylbenzene-1,2-diamine | [CAS]
97389-11-2 | [Synonyms]
4-Fluoro-5-methylbenzene-1,2-diamine
5-Fluoro-4-methylbenzene-1,2-diamine
4-fluoro-5-methyl-1,2-benzenediamine
1,2-Benzenediamine, 4-fluoro-5-methyl-
(2-amino-4-fluoro-5-methyl-phenyl)amine
4-Fluoro-5-methylphenylene-1,2-diamine, 4,5-Diamino-2-fluorotoluene | [Molecular Formula]
C7H9FN2 | [MDL Number]
MFCD17167315 | [MOL File]
97389-11-2.mol | [Molecular Weight]
140.16 |
| Chemical Properties | Back Directory | [Boiling point ]
273.5±35.0 °C(Predicted) | [density ]
1.224±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
4.34±0.10(Predicted) | [Appearance]
Brown to black Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 4 Synthesis of 5-fluoro-4-methylbenzene-1,2-diamine: 4-fluoro-5-methyl-2-nitroaniline (3.12 g, 0.018 mol), sodium dithionite (Na2S2O4, 9.58 g, 0.055 mol), water (45 mL), and ethanol (90 mL) were added to a 250 mL round bottom flask. The reaction mixture was heated to reflux and kept for 1 hour. Upon completion of the reaction, the solvent was removed by rotary evaporator. The residue was suspended in a mixture of triethylamine (15 mL) and ethyl acetate (300 mL) and subsequently filtered. The filtrate was concentrated under reduced pressure to give 2.1 g (82% yield) of the target product 5-fluoro-4-methylbenzene-1,2-diamine as a light red solid. | [References]
[1] Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1985, vol. 39, # 3, p. 213 - 217
[2] Patent: US2010/120741, 2010, A1. Location in patent: Page/Page column 35
[3] Patent: WO2011/112731, 2011, A2. Location in patent: Page/Page column 101 |
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| Company Name: |
Cochemical Ltd.
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029-86115547 17791676824 |
| Website: |
www.cochemical.com |
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