| Identification | Back Directory | [Name]
MERBARONE | [CAS]
97534-21-9 | [Synonyms]
MERBARONE
NSC-336628
Merbarone - CAS 97534-21-9 - Calbiochem
5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID
5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID
5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628
hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid
4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide
5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo- | [Molecular Formula]
C11H9N3O3S | [MDL Number]
MFCD00866337 | [MOL File]
97534-21-9.mol | [Molecular Weight]
263.27 |
| Chemical Properties | Back Directory | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >5mg/mL | [form ]
solid | [pka]
-2.16±0.20(Predicted) | [color ]
Pink to purple | [InChI]
1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18) | [InChIKey]
GFYRZTLCYQQVHZ-UHFFFAOYSA-N | [SMILES]
Sc1nc(c(c(n1)O)C(=O)Nc2ccccc2)O |
| Hazard Information | Back Directory | [Uses]
Merbarone has been used to study its effect on the occurrence of DNA lesions. | [General Description]
A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 μM for purified mammalian topo II versus IC50 = ~ 200 μM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism. | [Biochem/physiol Actions]
Cell permeable: yes | [in vivo]
Merbarone (50 mg/kg; daily i.p. for 5 d) achieves a maximum increased life span (ILS) of 101% in P388 murine leukemia[2].
Merbarone (124 mg/kg; daily p.o. for 9 d) has anti-tumor activity in mice[2]. |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|