| Identification | Back Directory | [Name]
QUINELORANE 2HCL | [CAS]
97548-97-5 | [Synonyms]
QUINELORANE 2HCL
Quinelorane hydrochloride
QUINELORANE DIHYDROCHLORIDE (LY-163,502) D2 DOPAMINE RECEPTOR
(5aR,9aR)-5,5a,6,7,8,9,9a,10-Octahydro-6-propylpyrido[2,3-g]quinazolin-2-aminedihydrochloride
LY-163,502, (5aR-trans)-5,5a,6,7,8,9,9a,10-Octahydro-6-propylpyrido[2,3-g]quinazolin-2-amine dihydrochloride | [Molecular Formula]
C14H23ClN4 | [MDL Number]
MFCD00903730 | [MOL File]
97548-97-5.mol | [Molecular Weight]
282.82 |
| Hazard Information | Back Directory | [Uses]
Antihypertensive; antiparkinsonian. | [Uses]
Quinelorane Dihydrochloride is a D2DR agonist. | [Biological Activity]
Dopamine D 2 and D 3 receptor agonist; K i values are 5.7 and 3.4 nM respectively. | [in vivo]
Quinelorane dihydrochloride (LY163502; 0.003, 0.01 mg/kg; s.c.) reduces GABA efflux, with significant effects with 0.01 but not 0.003 mg/kg in male Wistar rats (300 g)[1].
Quinelorane dihydrochloride (0.032, 0.32, 3.2, 5.6 mg/kg; IP) significantly and dose-dependently increases locomotor activity in the Sprague Dawley rats. There was no main effect of sex and sex interaction[1].
Quinelorane dihydrochloride significantly decreases activity in the male and female inbred FVB/NJ, BALB/cJ, BALB/cByJ, C57BL/6J, Swiss Webster, A/J, DBA/2J, 129S1/SvImJ, and 129S6/SvEvTac mice[1].
| [IC 50]
D2 Receptor; D3 Receptor | [storage]
Desiccate at RT |
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