| Identification | Back Directory | [Name]
2'-Azido-2'-deoxy-5-methyluridine | [CAS]
97748-75-9 | [Synonyms]
2'-Azido-2'-deoxy-5-methyluridine
1-(2'-azido-2'-deoxy-β-β-D-ribofuranosyl)thymine
1-[3-AZIDO-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE | [Molecular Formula]
C10H13N5O5 | [MDL Number]
MFCD17215639 | [MOL File]
97748-75-9.mol | [Molecular Weight]
283.24 |
| Hazard Information | Back Directory | [Uses]
2′-Azido-2′-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2′-Azido-2′-deoxy-5-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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