ChemicalBook--->CAS DataBase List--->97792-39-7

97792-39-7

97792-39-7 Structure

97792-39-7 Structure
IdentificationBack Directory
[Name]

Z-GLY-GLY-LEU-AMC
[CAS]

97792-39-7
[Synonyms]

Z-GGL-AMC
Z-GLY-GLY-LEU-AMC
CBZ-Gly-Gly-Leu-AMC
Proteasome Substrate
PROTEASOME SUBSTRATE V, FLUOROGENIC
7-(N-benzyloxycarbonylglycyl-glycyl-leucyl)amino-4-methylcoumarin
7-(Nα-benzyloxycarbonyl-glycylglycyl-L-leucyl)amino-4-methylcoumarin
N-[(Phenylmethoxy)carbonyl]glycylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-leucinamide
L-Leucinamide, N-[(phenylmethoxy)carbonyl]glycylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
Carbobenzoxy-Gly-Gly-Leu-7-amido-4-methylcoumarin, benzyloxycarbonyl-glycyl-glycyl-leucyl-7-amido-4-methylcoumarin
[Molecular Formula]

C28H32N4O7
[MDL Number]

MFCD00152029
[MOL File]

97792-39-7.mol
[Molecular Weight]

536.58
Chemical PropertiesBack Directory
[storage temp. ]

-15°C
[form ]

White powder.
[Sequence]

{Cbz}-Gly-Gly-Leu-{AMC}
Safety DataBack Directory
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

Z-GGL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 20S proteasome. It is a sensitive fluorogenic substrate for subtilisins BPN'' and Carlsberg.
[Biological Activity]

Z-Gly-Gly-Leu-7-amido-4-methylcoumarin (Z-Gly-Gly-Leu-AMC) is a fluorogenic peptide th at is used in analysis of protease and peptidase activity of proteasomes. Z-GGL-AMC has been noted as a particular substrate for chymotrypsin-like activity. It has low solubility and precipitates at 100μM.
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