ChemicalBook--->CAS DataBase List--->97799-98-9

97799-98-9

97799-98-9 Structure

97799-98-9 Structure
IdentificationBack Directory
[Name]

2-ThiophenecarboxaMide, 5-chloro-N-Methyl-
[CAS]

97799-98-9
[Synonyms]

Rivaroxaban K
Rivaroxaban impurity P2-S
Rivaroxaban CMTCA Impurity
5-Chloro-N-methylthiophene-2-carboxamide
2-Thiophenecarboxamide, 5-chloro-N-methyl-
5-chloro-2-thiophenecarboxylic acid N-methylamide
Rivaroxaban impurity N: 5-chlorothiophene-2-carboxamide
Imp. D:5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide
2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ISO 9001:2015 REACH
2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ExperiMental Properties
Rivaroxaban Impurity 18/5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide
Rivaroxaban Related Compound (5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide)
[Molecular Formula]

C6H6ClNOS
[MDL Number]

MFCD00508500
[MOL File]

97799-98-9.mol
[Molecular Weight]

175.64
Chemical PropertiesBack Directory
[Melting point ]

164-166°C
[storage temp. ]

Refrigerator
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[color ]

White to Off-White
Hazard InformationBack Directory
[Uses]

5-Chloro-N-methylthiophene-2-carboxamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.
[Synthesis]

Step ① add 5-chlorothiophene-2-carboxylic acid, dichloromethane, dichlorosulfoxide dropwise at 0 ℃, dropwise addition, room temperature stirring for 4 hours;

Step ② dropwise addition of aqueous solution with a mass concentration of 40% of methyla

Spectrum DetailBack Directory
[Spectrum Detail]

2-ThiophenecarboxaMide, 5-chloro-N-Methyl-(97799-98-9)1HNMR
2-ThiophenecarboxaMide, 5-chloro-N-Methyl-(97799-98-9)13CNMR
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