| Identification | Back Directory | [Name]
tibenelast | [CAS]
97852-72-7 | [Synonyms]
LY-186655
tibenelast
5,6-Diethoxybenzo[b]thiophene-2-carboxylic acid
Benzo[b]thiophene-2-carboxylic acid, 5,6-diethoxy- | [Molecular Formula]
C13H14O4S | [MDL Number]
MFCD00890221 | [MOL File]
97852-72-7.mol | [Molecular Weight]
266.31 |
| Hazard Information | Back Directory | [Uses]
Tibenelast (LY186655) free acid is a potent and orally active is a phosphodiesterase inhibitor. Tibenelast free acid is an anti-asthma agent Tibenelast free acid increases the heart rate response to isoproterenol (HY-108353). Tibenelast free acid shows anti-anaphylactic shock activity. Tibenelast free acid has the potential for the research of asthma and other respiratory diseases[1][2]. | [References]
[1] Ho PP, et al. Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig. Life Sci. 1990;46(13):917-25. DOI:10.1016/0024-3205(90)90093-7
[2] Schwertschlag US, et al. Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46(3):142-7. DOI:10.1159/000139039 |
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