| Identification | Back Directory | [Name]
Flesinoxan | [CAS]
98205-89-1 | [Synonyms]
Flesinoxan HCl
4-fluoro-N-[2-[4-[(2S)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-5-yl]piperazin-1-yl]ethyl]benzamide
Benzamide, N-(2-(4-(2,3-dihydro-2-(hydroxymethyl)-1,4-benzodioxin-5-yl)-1-piperazinyl)ethyl)-4-fluoro-, monohydrochloride
Benzamide, N-(2-(4-((2R)-2,3-dihydro-2-(hydroxymethyl)-1,4-benzodioxin-5-yl)-1-piperazinyl)ethyl)-4-fluoro-, monohydrochloride | [Molecular Formula]
C22H27ClFN3O4 | [MOL File]
98205-89-1.mol | [Molecular Weight]
451.919 |
| Hazard Information | Back Directory | [Uses]
Flesinoxan hydrochloride is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan hydrochloride also has effective anxiolytic/antidepressant effects[1][2][3]. | [References]
[1] Hadrava V, et al. Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Neuropharmacology. 1995 Oct;34(10):1311-26. DOI:10.1016/0028-3908(95)00098-q
[2] Schoeffter P, et al. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br J Pharmacol. 1988 Nov;95(3):975-85. DOI:10.1111/j.1476-5381.1988.tb11728.x
[3] Rodgers RJ, et al. Antianxiety and behavioral suppressant actions of the novel 5-HT1A receptor agonist, flesinoxan. Pharmacol Biochem Behav. 1994 Aug;48(4):959-63. DOI:10.1016/0091-3057(94)90205-4 |
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Leancare Ltd.
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+33 962096793 |
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www.leancare.co.uk |
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