| Identification | Back Directory | [Name]
valclavam | [CAS]
98359-78-5 | [Synonyms]
valclavam
Antibiotic Tu-1718z
Threonine, L-valyl-4-[(3S,5S)-7-oxo-4-oxa-1-azabicyclo[3.2.0]hept-3-yl]-
β-[(2-Amino-3-methyl-1-oxobutyl)amino]-α-hydroxy-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-3-butanoic acid
2-[(2-amino-3-methylbutanoyl)amino]-3-hydroxy-4-(7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-3-yl)butanoic acid | [Molecular Formula]
C14H23N3O6 | [MOL File]
98359-78-5.mol | [Molecular Weight]
329.35 |
| Hazard Information | Back Directory | [Uses]
Valclavam is an antibiotic, which exhibits antibacterial and antifungal activities. Valclavam inhibits homoserine-O-succinyltransferase (EC 2.3.1.46), blocks the methionine synthesis, and thus inhibits Escherichia coli. Valclavam inhibits Saccharomyces cerevisiae through inhibition of RNA formation. Valclavam inhibits the movement and reproduction of nematode Caenorhabditis elegans. | [References]
[1] R?hl F, et al., Biological properties and mode of action of clavams. Arch Microbiol. 1987 May;147(4):315-20. DOI:10.1007/BF00406126 |
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